Sodium sulfate decahydrate → (4-Phenylsulfanylmethyl-phenyl)-methanol

HRID 926994

반응식

HRID 926994 반응식
[C:1]1([S:7][CH2:8][C:9]2[CH:18]=[CH:17][C:12]([C:13](OC)=[O:14])=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+]>C1COCC1>[C:1]1([S:7][CH2:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:13][OH:14])=[CH:17][CH:18]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 62649Sodium sulfate decahydrateHCID 366566Methyl 4-(phenylsulfanylmethyl)benzoateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 59255239(4-Phenylsulfanylmethyl-phenyl)-methanol수율 95.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Methyl 4-(phenylsulfanylmethyl)benzoate (1.07 g) was dissolved in THF (14 mL), added with lithium aluminum hydride (200 mg) in small portions under ice cooling, and stirred for 40 minutes at the same temperature. Under ice cooling, sodium sulfate decahydrate was added in small portions and filtered through Celite. The solvent was evaporated under reduced pressure. The residues were suspended in hexane and collected by filtration to obtain the title compound (910 mg) as a white powder.

후처리

  1. filtrationfiltered through Celite
  2. customThe solvent was evaporated under reduced pressure
  3. filtrationcollected by filtration

출처 및 근거

ORD 기록
ord-515455be59cd4491a9782fc76afb926c
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290440B2

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