4-Iodo-1,2-dimethoxybenzene → HCID 71270121, 화합물

HRID 927083

반응식

HRID 927083 반응식
C(OC1N=NC(C#CC2C=CC(C(F)(F)F)=CN=2)=CC=1OCC1C=CC=CC=1)C1C=CC=CC=1.[CH2:35]([O:42][C:43]1[N:44]=[N:45][C:46]([C:57]#[CH:58])=[CH:47][C:48]=1[O:49][CH2:50][C:51]1[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=1)[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1.I[C:60]1[CH:65]=[CH:64][C:63]([O:66][CH3:67])=[C:62]([O:68][CH3:69])[CH:61]=1>>[CH2:35]([O:42][C:43]1[N:44]=[N:45][C:46]([C:57]#[C:58][C:60]2[CH:65]=[CH:64][C:63]([O:66][CH3:67])=[C:62]([O:68][CH3:69])[CH:61]=2)=[CH:47][C:48]=1[O:49][CH2:50][C:51]1[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=1)[C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1

참가 물질

4

반응물 3

HCID 2303074-Iodo-1,2-dimethoxybenzeneHCID 712699103,4-Bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazine2회HCID 86677025HCID 86677025, 화합물2회

생성물 1

HCID 71270121HCID 71270121, 화합물수율 17%

실험 절차

Prepared as described for 3,4-bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazine (Intermediate 6) from 3,4-bis(benzyloxy)-6-ethynylpyridazine (Intermediate 5) and 4-iodo-1,2-dimethoxybenzene in 17% yield.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-10bb13aa6f14400a9d4fed4e9ef9142b
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290456B2

연결된 노트

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