Hydrochloric Acid → 3-[1-(3-Fluorophenyl)methylidene]piperidine hydrochloride

HRID 928079노트

반응식

HRID 928079 반응식
[ClH:1].[F:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]2[CH2:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11]2)[CH:6]=[CH:7][CH:8]=1>O1CCOCC1.CCOCC>[ClH:1].[F:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]2[CH2:15][CH2:14][CH2:13][NH:12][CH2:11]2)[CH:6]=[CH:7][CH:8]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 86713375Tert-butyl 3-[1-(3-fluorophenyl)methylidene]piperidine-1-carboxylate2회

생성물 1

HCID 709838913-[1-(3-Fluorophenyl)methylidene]piperidine hydrochloride

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 312751,4-Dioxane용매

실험 절차

A solution of HCl in dioxane (4M, 30 mL) was added to a solution of tert-butyl 3-[1-(3-fluorophenyl)methylidene]piperidine-1-carboxylate (Intermediate 227, 2.38 g) in ether (30 mL) and the mixture was stirred at room temperature for 5 hours. The mixture was concentrated in vacuo and the residue was treated with ether. The solid was collected by filtration, washed with ether and dried under vacuum to give 3-[1-(3-fluorophenyl)methylidene]piperidine hydrochloride (1.64 g).

후처리

  1. concentrationThe mixture was concentrated in vacuo
  2. additionthe residue was treated with ether
  3. filtrationThe solid was collected by filtration
  4. washwashed with ether
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-1444adab56f54a87a3b0ccc60405ac1f
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290472B2

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