Cyclobutylamine → HCID 118073613, 화합물

HRID 928185

반응식

HRID 928185 반응식
[CH:1]1([NH2:5])[CH2:4][CH2:3][CH2:2]1.[Cl:6][C:7]1[N:12]=[C:11](Cl)[C:10]([N+:14]([O-:16])=[O:15])=[C:9]([Cl:17])[N:8]=1.CCN(C(C)C)C(C)C>CC(O)C>[Cl:6][C:7]1[N:12]=[C:11]([NH:5][CH:1]2[CH2:4][CH2:3][CH2:2]2)[C:10]([N+:14]([O-:16])=[O:15])=[C:9]([Cl:17])[N:8]=1

참가 물질

5

반응물 3

HCID 75645CyclobutylamineHCID 81531DiisopropylethylamineHCID 42978432,4,6-Trichloro-5-nitropyrimidine

생성물 1

HCID 118073613HCID 118073613, 화합물

시약·촉매·용매 1

HCID 3776Isopropanol용매2회

실험 절차

Cyclobutanamine (0.485 mL, 5.68 mmol) in iPrOH (20 mL) was added to a solution of 2,4,6-trichloro-5-nitropyrimidine (1.29 g, 5.65 mmol) in iPrOH (40 mL) at −78° C. dropwise via addition funnel. After complete addition, the mixture was allowed to warm to rt over 30 min, then DIEA (0.940 mL, 5.66 mmol) was added and the mixture stirred at rt for 10 min. The solvent was removed under reduced pressure and dried to give the title compound as a pale yellow oil which was used without purification.

후처리

  1. additionAfter complete addition
  2. customThe solvent was removed under reduced pressure
  3. customdried

출처 및 근거

ORD 기록
ord-c66db0927f9b4d98b64b1e04e327001f
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290496B2

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