Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 2-(5-Bromo-2-fluorophenyl)-4-Chloropteridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 2-(5-Bromo-2-fluoro-phenyl)-3H-pteridin-4-one | HCID 136109958 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-(5-Bromo-2-fluorophenyl)-4-Chloropteridine | HCID 57742381 | 99.3% |
반응 단계
Thionyl chloride (371 mg, 3.11 mmol) was added to the stirred suspension of 2-(5-bromo-2-fluorophenyl)pteridin-4-one 104 (200 mg, 0.623 mmol) in chloroform (5 mL) and dry DMF (100 μL). The reaction mixture was refluxed under nitrogen for 1 h (starting material gone by HPLC). The solvent was removed in vacuo. Then the residue was triturated in Et2O and filtered off to give 210 mg of the title product 106 as a yellow solid (LCMS analysis).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09290502B2 |
| 출처 데이터셋 | uspto-grants-2016_03 |
| ORD ID | ord-66c332a926ac4642aa5cca4f7bd70f04 |
| 출처 메모 | uspto-grants-2016_03 |