Sodium Hydroxide → 4-[[2-(5-Bromo-2-fluorophenyl)pteridin-4-yl]amino]nicotinic Acid

HRID 928266

반응식

HRID 928266 반응식
C[O:2][C:3](=[O:29])[C:4]1[C:9]([NH:10][C:11]2[C:20]3[C:15](=[N:16][CH:17]=[CH:18][N:19]=3)[N:14]=[C:13]([C:21]3[CH:26]=[C:25]([Br:27])[CH:24]=[CH:23][C:22]=3[F:28])[N:12]=2)=[CH:8][CH:7]=[N:6][CH:5]=1.[OH-].[Na+]>C1COCC1.CO.O>[Br:27][C:25]1[CH:24]=[CH:23][C:22]([F:28])=[C:21]([C:13]2[N:12]=[C:11]([NH:10][C:9]3[C:4]([C:3]([OH:29])=[O:2])=[CH:5][N:6]=[CH:7][CH:8]=3)[C:20]3[C:15](=[N:16][CH:17]=[CH:18][N:19]=3)[N:14]=2)[CH:26]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 577423794-[[2-(5-Bromo-2-fluorophenyl)pteridin-4-yl]amino]nicotinic Acid Methyl Ester

생성물 1

HCID 577423744-[[2-(5-Bromo-2-fluorophenyl)pteridin-4-yl]amino]nicotinic Acid수율 82.6%

시약·촉매·용매 1

HCID 21892291Methanol tetrahydrofuran water용매

실험 절차

A solution of 4-[[2-(5-bromo-2-fluorophenyl)pteridin-4-yl]amino]nicotinic acid methyl ester 107 (200 mg, 0.439 mmol) and NaOH (44 mg, 1.10 mmol) in THF/MeOH/H2O (3:2:1, 5 mL), was stirred at room temperature for 3 h. The solvent was evaporated, and the residue dissolved in H2O, neutralized with AcOH, filtered off, and successively washed with H2O, MeOH and Ether to give 160 mg of the title product 16 as a yellow powder (LCMS analysis).

후처리

  1. customThe solvent was evaporated
  2. dissolutionthe residue dissolved in H2O
  3. filtrationfiltered off
  4. washsuccessively washed with H2O, MeOH and Ether

출처 및 근거

ORD 기록
ord-736403cc896f4faca428dd875149340e
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290502B2

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