L-Thioproline → HCID 89555447, 화합물

HRID 928679

반응식

HRID 928679 반응식
[F:1][C:2]1[C:7]2[CH:8]=[CH:9][O:10][C:6]=2[C:5]([C:11]2[CH:27]=[CH:26][C:14]([O:15][CH2:16][C:17]3[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=3)[C:20](O)=[O:21])=[CH:13][CH:12]=2)=[CH:4][C:3]=1[F:28].[S:29]1[CH2:33][C@@H:32]([C:34]([OH:36])=[O:35])[NH:31][CH2:30]1>>[F:1][C:2]1[C:7]2[CH:8]=[CH:9][O:10][C:6]=2[C:5]([C:11]2[CH:12]=[CH:13][C:14]([O:15][CH2:16][C:17]3[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=3)[C:20]([N:31]3[C@H:32]([C:34]([OH:36])=[O:35])[CH2:33][S:29][CH2:30]3)=[O:21])=[CH:26][CH:27]=2)=[CH:4][C:3]=1[F:28]

참가 물질

3

반응물 2

HCID 93176L-ThioprolineHCID 90384393HCID 90384393, 화합물

생성물 1

HCID 89555447HCID 89555447, 화합물수율 2.8%

실험 절차

An operation similar to that in Step 4 of Example 10 was performed using the compound (38.0 mg, 0.100 mmol) of Step 2 of Example 59 in place of 3-{[4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)phenoxy]methyl}benzoic acid, and (4R)-1,3-thiazolidine-4-carboxylic acid (40.0 mg, 0.300 mmol) in place of L-proline to thus obtain the title compound.

출처 및 근거

ORD 기록
ord-9070fffa867244d19d5b2d6540a8eedc
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290487B2

연결된 노트

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