Benzocaine → Ethyl 3-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-6-carboxylate

HRID 928764

반응식

HRID 928764 반응식
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][CH:3]=1.[CH2:13]([CH:20]([C:33](OC1C(Cl)=CC(Cl)=CC=1Cl)=[O:34])[C:21](OC1C(Cl)=CC(Cl)=CC=1Cl)=[O:22])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CCOCC>[CH2:13]([C:20]1[C:21](=[O:22])[NH:1][C:2]2[C:3]([C:33]=1[OH:34])=[CH:4][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:11][CH:12]=2)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

4

반응물 2

HCID 2337BenzocaineHCID 2782299Bis(2,4,6-trichlorophenyl) benzylpropanedioate

생성물 1

HCID 54697379Ethyl 3-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-6-carboxylate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of ethyl 4-aminobenzoate (2.85 g, 17.2 mmol) and bis(2,4,6-trichlorophenyl) 2-benzylmalonate (11.4 g, 20.7 mmol, Intermediate 33: step a) was microwaved at 250° C. for 15 minutes (Biotage Initiator). The reaction was then allowed to cool to room temperature, and the resulting tan semisolid was dispersed in ether (15 mL) and filtered. The beige filter cake was washed with ether (1×15 mL) and dried at 100° C. to provide the title compound as a light beige powder.

후처리

  1. customstep a) was microwaved at 250° C. for 15 minutes (Biotage Initiator)
  2. filtrationfiltered
  3. washThe beige filter cake was washed with ether (1×15 mL)
  4. customdried at 100° C.

출처 및 근거

ORD 기록
ord-2cf16a079a814bd8bd9da47b81f75e4f
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290476B2

연결된 노트

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