Sodium Hydroxide → HCID 71504585, 화합물

HRID 929357노트

반응식

HRID 929357 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[N:10][C:11]3[C:16]([N:17]=2)=[CH:15][C:14]([C:18]([C:20]2[C:21]([F:41])=[C:22]([N:28](S(CCC)(=O)=O)[S:29]([CH2:32][CH2:33][CH3:34])(=[O:31])=[O:30])[CH:23]=[C:24]([F:27])[C:25]=2[F:26])=[O:19])=[CH:13][CH:12]=3)=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[N:10][C:11]3[C:16]([N:17]=2)=[CH:15][C:14]([C:18]([C:20]2[C:21]([F:41])=[C:22]([NH:28][S:29]([CH2:32][CH2:33][CH3:34])(=[O:31])=[O:30])[CH:23]=[C:24]([F:27])[C:25]=2[F:26])=[O:19])=[CH:13][CH:12]=3)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 86677181HCID 86677181, 화합물

생성물 1

HCID 71504585HCID 71504585, 화합물수율 60.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a N-(3-(3-(4-chlorophenyl)quinoxaline-6-carbonyl)-2,4,5-trifluorophenyl)-N-(propylsulfonyl)propane-1-sulfonamide (50 mg, 0.08 mmol, 1.0 eq.) in MeOH (5 mL) was added NaOH aqueous solution (1 N, 0.16 mL, 0.16 mmol, 2.0 eq.). The resulting mixture was stirred at rt for 1 h, then concentrated. The resulting residue was purified by flash column chromatography (PE/EA=2/1, v/v) to afford N-(3-(3-(4-chlorophenyl)quinoxaline-6-carbonyl)-2,4,5-trifluorophenyl)propane-1-sulfonamide (25 mg, 60.2%). LRMS (M−H+) m/z calculated 518.1, found 518.0. 1H NMR (CDCl3, 400 MHz) δ 9.42 s), 8.44 (s, 1 H), 8.27-8.38 (m, 2 H), 8.14-8.16 (dd, 2 H), 7.73-7.76 (m, 1 H), 7.55-7.57 (dd, 2 H), 6.55 (s, 1 H), 3.14-3.18 (m, 2 H), 1.88-1.94 (q, 2 H), 1.06-1.10 (t, 3 H).

후처리

  1. concentrationconcentrated
  2. customThe resulting residue was purified by flash column chromatography (PE/EA=2/1

출처 및 근거

ORD 기록
ord-94d4fe5056514abbbea3056ebd86abba
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09295671B2

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