참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4-bromo-7-methoxy-1-tosyl-1H-pyrrolo[2,3-c]pyridine | HCID 89657546 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 4-bromo-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one | HCID 89657580 | 94% |
반응 단계
A solution of Example 1c (12.4 g, 32.6 mmol) in dioxane (140 mL) was stirred at room temperature. To this solution was added 4M HCl in dioxane (140 mL). The reaction mixture was stirred at 40° C. for 16 hours. The reaction mixture was cooled to room temperature and concentrated. The residue was triturated with diethylether, filtered, and rinsed with additional diethylether and dried to provide the title compound (11.23 g, 30.6 mmol, 94% yield) as a beige solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09296741B2 |
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| 출처 데이터셋 | uspto-grants-2016_03 |
|---|
| ORD ID | ord-ede04b1e8a7f40ba94f817619411fce3 |
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| 출처 메모 | uspto-grants-2016_03 |
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