反应详情

温度

40 °C

A solution of Example 1c (12.4 g, 32.6 mmol) in dioxane (140 mL) was stirred at room temperature. To this solution was added 4M HCl in dioxane (140 mL). The reaction mixture was stirred at 40° C. for 16 hours. The reaction mixture was cooled to room temperature and concentrated. The residue was triturated with diethylether, filtered, and rinsed with additional diethylether and dried to provide the title compound (11.23 g, 30.6 mmol, 94% yield) as a beige solid.

1. temperatureThe reaction mixture was cooled to room temperature
2. concentrationconcentrated
3. customThe residue was triturated with diethylether
4. filtrationfiltered
5. washrinsed with additional diethylether
6. customdried