Tetrahydrofuran → 1469286-32-5

HRID 931073노트

반응식

HRID 931073 반응식
[N:1]1([C:6]2([C:10]([O:12]CC)=[O:11])[CH2:9][CH2:8][CH2:7]2)[CH:5]=[CH:4][CH:3]=[N:2]1.O1CCCC1.[OH-].[Na+]>O>[N:1]1([C:6]2([C:10]([OH:12])=[O:11])[CH2:7][CH2:8][CH2:9]2)[CH:5]=[CH:4][CH:3]=[N:2]1

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 89853540HCID 89853540, 화합물

생성물 1

HCID 898542991469286-32-5수율 18.5%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To ethyl 1-(1H-pyrazol-1-yl)cyclobutanecarboxylate (688 mg, 3.54 mmol) were added tetrahydrofuran (8 mL) and water (0.9 mL). Aqueous sodium hydroxide (1N, 4 mL, 4 mmol) was added to the mixture. The reaction mixture was stirred at room temperature for 18 h. The solvent was removed under reduced pressure and to the residue was added aqueous hydrochloric acid (1N, 1 mL). The mixture was extracted with dichloromethane (3×). The combined organics were dried over magnesium sulfate, filtered and concentrated under reduced pressure to afford the title compound (108.9 mg). The material was used without further purification.

후처리

  1. customThe solvent was removed under reduced pressure and to the residue
  2. additionwas added aqueous hydrochloric acid (1N, 1 mL)
  3. extractionThe mixture was extracted with dichloromethane (3×)
  4. dry with materialThe combined organics were dried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-16f5c9efd5a349688e59bd5abc6c5a17
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296745B2

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