Hydrochloric Acid → HCID 89855000, 화합물

HRID 931134노트

반응식

HRID 931134 반응식
[C:1]1([CH3:12])[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2([C:10]#[N:11])[CH2:9][CH2:8]2)[CH:2]=1.[ClH:13].[CH2:14]([OH:16])[CH3:15]>>[ClH:13].[C:1]1([CH3:12])[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2([C:10](=[NH:11])[O:16][CH2:14][CH3:15])[CH2:8][CH2:9]2)[CH:2]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 200261921-(3-Methylphenyl)cyclopropane-1-carbonitrile

생성물 1

HCID 89855000HCID 89855000, 화합물수율 96.5%

실험 절차

To 1-(m-tolyl)cyclopropanecarbonitrile (100 mg, 0.64 mmol) was added a saturated solution of hydrogen chloride in ethanol (2 mL). After 16 h at room temperature and 2 h at 70° C. and another 16 h at room temperature, the mixture was concentrated in vacuo and the residue was dried under high vacuum to afford the title compound (147.1 mg, 96.5%) as a colorless solid. MS (ES+) (M+H) 204.1, LCMS retention time: 3.10 minutes (Method L).

후처리

  1. concentration2 h at 70° C. and another 16 h at room temperature, the mixture was concentrated in vacuo
  2. customthe residue was dried under high vacuum

출처 및 근거

ORD 기록
ord-29f1b112b5944403b23c13204b957ed3
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296745B2

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