Hydrochloric Acid → (R)-piperidin-3-yl(pyrrolidin-1-yl)methanone

HRID 931180노트

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HRID 931180 반응식
[N:1]1([C:6]([C@@H:8]2[CH2:13][CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]2)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl>CO.O1CCOCC1>[NH:10]1[CH2:11][CH2:12][CH2:13][C@@H:8]([C:6]([N:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)=[O:7])[CH2:9]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 28167609(R)-tert-butyl 3-(pyrrolidine-1-carbonyl)piperidine-1-carboxylate

생성물 1

HCID 7169819(R)-piperidin-3-yl(pyrrolidin-1-yl)methanone

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매

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온도
30 °C

실험 절차

To a solution of (R)-tert-butyl 3-(pyrrolidine-1-carbonyl)piperidine-1-carboxylate in methanol (120 mL) was slowly added a solution of hydrogen chloride in 1,4-dioxane (30 mL, 4M). The mixture was stirred at 30° C. for 2 h. The solvent was removed under reduced pressure to afford (R)-piperidin-3-yl(pyrrolidin-1-yl)methanone, which was used in the next step without further purification.

후처리

  1. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-a3997c2fb02047c99f25e097ee8e3e45
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296745B2

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