Hydrochloric Acid → (-)-Nipecotic acid

HRID 931192노트

반응식

HRID 931192 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@@H:10]([C:14]([OH:16])=[O:15])[CH2:9]1)=O)(C)(C)C.Cl>ClCCl>[NH:8]1[CH2:13][CH2:12][CH2:11][C@@H:10]([C:14]([OH:16])=[O:15])[CH2:9]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 6435161-(1,1-Dimethylethyl) (3R)-1,3-piperidinedicarboxylate

생성물 1

HCID 1796510(-)-Nipecotic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
30 °C

실험 절차

To (R)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (7.0 mmol) was added dichloromethane (48 mL) followed by hydrochloric acid (4M, 16 mL). The reaction mixture was stirred at 30° C. for 2 h. The solvent was removed under reduced pressure to afford (R)-piperidine-3-carboxylic acid which was used without further purification.

후처리

  1. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-075cfefe530742c9a103d29b5ed0a298
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296745B2

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