Hydrochloric Acid → (-)-Nipecotic acid

HRID 931196노트

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HRID 931196 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@@H:10]([C:14]([OH:16])=[O:15])[CH2:9]1)=O)(C)(C)C.Cl>ClCCl.O1CCOCC1>[NH:8]1[CH2:13][CH2:12][CH2:11][C@@H:10]([C:14]([OH:16])=[O:15])[CH2:9]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 6435161-(1,1-Dimethylethyl) (3R)-1,3-piperidinedicarboxylate

생성물 1

HCID 1796510(-)-Nipecotic acid

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 312751,4-Dioxane용매

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온도
30 °C

실험 절차

To a solution of (R)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (12.25 mmol) in dichloromethane (84 mL) was added a solution of hydrogen chloride in 1,4-dioxane (28 mL, 4M). The reaction mixture was stirred at 30° C. for 2 h. The solvent was removed under reduced pressure to afford (R)-piperidine-3-carboxylic acid which was used without further purification.

후처리

  1. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-5fd8378b65ea47ea994e7fedc7b081c9
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296745B2

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