Hydrochloric Acid → Ethyl 4-methylpiperidine-3-carboxylate

HRID 931301노트

반응식

HRID 931301 반응식
Cl.[CH3:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH:4]1[C:9]([OH:11])=[O:10].[CH2:12](O)[CH3:13]>C(O)(=O)C>[CH3:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH:4]1[C:9]([O:11][CH2:12][CH3:13])=[O:10]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 136586094-Methylpiperidine-3-carboxylic acid

생성물 1

HCID 13658603Ethyl 4-methylpiperidine-3-carboxylate

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Hydrogen chloride gas was bubbled into a solution of 4-methylpiperidine-3-carboxylic acid (6.0 g, 41.90 mmol) in ethanol (150 mL) and acetic acid (30 mL) at 0° C. under a nitrogen atmosphere. The reaction mixture was heated at reflux for 48 h, then was cooled and was partitioned between water and ethyl acetate. The organic layer was dried over sodium sulfate, filtered and concentrated under reduced pressure to afford ethyl 4-methylpiperidine-3-carboxylate (5.0 g). The material was used without further purification.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 48 h
  3. temperaturewas cooled
  4. customwas partitioned between water and ethyl acetate
  5. dry with materialThe organic layer was dried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-915fa440dfb3481ebc20e592cac4db4c
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296745B2

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