Sodium Hydroxide → 4-[4-(Hydroxymethyl)-5-methyl-1,3-oxazol-2-yl]benzoic acid

참여 물질

역할	이름	HCID	투입량
반응물	Sodium Hydroxide	HCID 14798	—
반응물	Methyl 4-(4-(chloromethyl)-5-methyloxazol-2-yl)benzoate	HCID 23076573	—
생성물	4-[4-(Hydroxymethyl)-5-methyl-1,3-oxazol-2-yl]benzoic acid	HCID 68278425	72%

반응 단계

Reaction of chloride 2 (500 mg, 1.88 mmol) and aqueous NaOH (2 M, 10 mL, 20 mmol) gave acid 55 (313 mg, 72%) as a cream solid: mp (EtOAc/MeOH) 240-242° C.; 1H NMR δ □ 13.18 (br s, 1H, CO2H), 8.00-8.06 (m, 4H, H-2, H-3, H-5, H-6), 5.11 (br s, 1H, OH), 2.41 (s, 3H, CH3); MS m/z 234.5 (MH+, 100%); HRMS calcd for C12H12NO4: 234.0761. Found: 234.0760.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09296732B2
출처 데이터셋	uspto-grants-2016_03
ORD ID	ord-7c7e2eadb1e94dbfb764c3b4d32d7c6c
출처 메모	uspto-grants-2016_03