反应详情

Reaction of chloride 2 (500 mg, 1.88 mmol) and aqueous NaOH (2 M, 10 mL, 20 mmol) gave acid 55 (313 mg, 72%) as a cream solid: mp (EtOAc/MeOH) 240-242° C.; 1H NMR δ □ 13.18 (br s, 1H, CO2H), 8.00-8.06 (m, 4H, H-2, H-3, H-5, H-6), 5.11 (br s, 1H, OH), 2.41 (s, 3H, CH3); MS m/z 234.5 (MH+, 100%); HRMS calcd for C12H12NO4: 234.0761. Found: 234.0760.