Tetrahydrofuran → 1-(3-Chloro-1-oxopropyl)-1,2-dihydro-4-[3-(trifluoromethyl)phenyl]imidazo[1,5-a]pyrimidine-8-carbonitrile

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[CH3:22][N:23]([CH3:24])[c:25]1[c:26]2[c:27]([cH:28][cH:29][cH:30][c:31]2[N:32]([CH3:33])[CH3:34])[cH:35][cH:36][cH:37]1.[CH3:38][N:39]([CH3:40])[c:41]1[c:42]2[c:43]([cH:44][cH:45][cH:46][c:47]2[N:48]([CH3:49])[CH3:50])[cH:51][cH:52][cH:53]1.[Cl:54][CH2:55][CH2:56][C:57](=[O:58])[Cl:59].[F:1][C:2]([c:3]1[cH:4][c:5]([C:9]2=[CH:10][CH2:11][NH:12][c:13]3[n:14]2[cH:15][n:16][c:17]3[C:18]#[N:19])[cH:6][cH:7][cH:8]1)([F:20])[F:21].[O:60]1[CH2:61][CH2:62][CH2:63][CH2:64]1>>[F:1][C:2]([c:3]1[cH:4][c:5]([C:9]2=[CH:10][CH2:11][N:12]([C:57]([CH2:56][CH2:55][Cl:54])=[O:58])[c:13]3[n:14]2[cH:15][n:16][c:17]3[C:18]#[N:19])[cH:6][cH:7][cH:8]1)([F:20])[F:21]