Hydrochloric Acid → N-(4-aminobutyl)methanesulfonamide hydrochloride

HRID 9404

반응식

HRID 9404 반응식
[ClH:1].[CH3:2][S:3]([NH:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)(=[O:5])=[O:4]>C(O)C>[ClH:1].[NH2:11][CH2:10][CH2:9][CH2:8][CH2:7][NH:6][S:3]([CH3:2])(=[O:5])=[O:4]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 54180899Tert-butyl[4-(methanesulfonylamino)butyl]carbamate

생성물 1

HCID 21984197N-(4-aminobutyl)methanesulfonamide hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매2회

반응 조건

온도
100 °C

실험 절차

A solution of hydrochloric acid in ethanol was added to a solution of tert-butyl [4-(methanesulfonylamino)butyl]carbamate (18.9 g, 71.1 mmol) in ethanol (100 mL), and the reaction was heated at 100° C. for two hours. The solvent was removed under reduced pressure. A mixture of dichloromethane:hexanes was added to the resulting oil and removed under reduced pressure; this process was repeated several times. The residue was dried for three days under vacuum to provide 14.3 g of N-(4-aminobutyl)methanesulfonamide hydrochloride as a tan solid.

후처리

  1. customThe solvent was removed under reduced pressure
  2. additionA mixture of dichloromethane
  3. additionhexanes was added to the resulting oil
  4. customremoved under reduced pressure
  5. customThe residue was dried for three days under vacuum

출처 및 근거

ORD 기록
ord-3e1f5abfa6d942d1a82cf7baca23135b
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091214B2

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