Pyridine → 1-(4-Chloro-phenylcarbamoyl)-5-(3-fluoro-2'-methanesulfonyl-biphenyl-4-ylcarbamoyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester

반응식

[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[C:6]1=[N:7][NH:8][CH:9]([C:11]([NH:12][c:13]2[c:14]([F:29])[cH:15][c:16](-[c:19]3[c:20]([S:25](=[O:26])(=[O:27])[CH3:28])[cH:21][cH:22][cH:23][cH:24]3)[cH:17][cH:18]2)=[O:30])[CH2:10]1.[CH2:47]([Cl:48])[Cl:49].[Cl:37][c:38]1[cH:39][cH:40][c:41]([N:44]=[C:45]=[O:46])[cH:42][cH:43]1.[cH:31]1[cH:32][cH:33][n:34][cH:35][cH:36]1>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[C:6]1=[N:7][N:8]([C:45]([NH:44][c:41]2[cH:40][cH:39][c:38]([Cl:37])[cH:43][cH:42]2)=[O:46])[CH:9]([C:11]([NH:12][c:13]2[c:14]([F:29])[cH:15][c:16](-[c:19]3[c:20]([S:25](=[O:26])(=[O:27])[CH3:28])[cH:21][cH:22][cH:23][cH:24]3)[cH:17][cH:18]2)=[O:30])[CH2:10]1