Trifluoromethylsulfonamide → 3,4,4-trifluoro-N-[(trifluoromethyl)sulfonyl]-3-butenamide

HRID 947

반응식

HRID 947 반응식
[F:1][C:2]([F:8])([F:7])[S:3]([NH2:6])(=[O:5])=[O:4].[F:9][C:10](=[C:15]([F:17])[F:16])[CH2:11][C:12](Cl)=[O:13]>[OH-].[Na+]>[F:9][C:10](=[C:15]([F:17])[F:16])[CH2:11][C:12]([NH:6][S:3]([C:2]([F:8])([F:7])[F:1])(=[O:5])=[O:4])=[O:13]

참가 물질

4

반응물 2

HCID 79001TrifluoromethylsulfonamideHCID 109207893,4,4-Trifluoro-3-butenoyl chloride

생성물 1

HCID 153350263,4,4-trifluoro-N-[(trifluoromethyl)sulfonyl]-3-butenamide수율 16.4%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

To an ice-cooled solution of trifluoromethanesulfonamide (2.75 g, 18.4 mmol) in 7.4 mL of 2.5 N sodium hydroxide was added 3,4,4-trifluoro-3-butenoyl chloride (2.93 g, 18.5 mmol) with stirring in 2 min. The mixture was stirred in cold for 30 min and the white precipitate formed was filtered, washed with cold water (10 mL) and dried to give 0.82 g (16%) of the desired product as a white solid. m.p. 115°-120° C.

후처리

  1. stirringThe mixture was stirred in cold for 30 min
  2. customthe white precipitate formed
  3. filtrationwas filtered
  4. washwashed with cold water (10 mL)
  5. customdried

출처 및 근거

ORD 기록
ord-e1a0dc1a113c454bac338b6a5d18d9a1
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723470

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