4-Aminomethyltetrahydropyran → (7-Bromo-3-nitroquinolin-4-yl)(tetrahydropyran-4-ylmethyl)amine

HRID 9470

반응식

HRID 9470 반응식
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](Cl)=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[N:9]2)=[CH:4][CH:3]=1.[O:16]1[CH2:21][CH2:20][CH:19]([CH2:22][NH2:23])[CH2:18][CH2:17]1>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:23][CH2:22][CH:19]3[CH2:20][CH2:21][O:16][CH2:17][CH2:18]3)=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[N:9]2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 27732104-AminomethyltetrahydropyranHCID 219843617-Bromo-4-chloro-3-nitroquinoline

생성물 1

HCID 21984259(7-Bromo-3-nitroquinolin-4-yl)(tetrahydropyran-4-ylmethyl)amine수율 94.3%

실험 절차

The method described in Part E of Examples 431–436 was used to treat 7-bromo-4-chloro-3-nitroquinoline (12.43 g, 43.45 mmol) with C-(tetrahydropyran-4-yl)methylamine (10 g, 87 mmol) to provide 15.0 g of (7-bromo-3-nitroquinolin-4-yl)(tetrahydropyran-4-ylmethyl)amine as a bright yellow solid.

출처 및 근거

ORD 기록
ord-f146f725e49749349a288d4b0e2fcd92
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091214B2

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