Hydrochloric Acid → 8-(1-Piperazinyl)-5-(trifluoromethyl)quinoline

반응식

[ClH:28].[F:1][C:2]([c:3]1[c:4]2[cH:5][cH:6][cH:7][n:8][c:9]2[c:10]([N:13]2[CH2:14][CH2:15][N:16]([C:19]([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:25])[CH2:17][CH2:18]2)[cH:11][cH:12]1)([F:26])[F:27].[O:29]1[CH2:30][CH2:31][O:32][CH2:33][CH2:34]1.[O:35]1[CH2:36][CH2:37][O:38][CH2:39][CH2:40]1>>[F:1][C:2]([c:3]1[c:4]2[cH:5][cH:6][cH:7][n:8][c:9]2[c:10]([N:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)[cH:11][cH:12]1)([F:26])[F:27]

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 312751,4-Dioxane2회

HCID 59204861Tert-butyl 4-[5-(trifluoromethyl)-8-quinolinyl]-1-piperazine-carboxylate

생성물 1

HCID 592048478-(1-Piperazinyl)-5-(trifluoromethyl)quinoline

출처 및 근거

ORD 기록: ord-ef71aee96d684cea9dfe8601d82b99e9
출처 데이터셋: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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