Ethyl bromoacetate → Ethyl 2-(2-(trifluoromethyl)phenoxy)acetate

HRID 9623

반응식

HRID 9623 반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9].C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]>C(#N)C.O.C(OCC)(=O)C>[CH2:23]([O:22][C:20](=[O:21])[CH2:19][O:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:10])([F:11])[F:1])[CH3:24]

참가 물질

7

반응물 3

HCID 7748Ethyl bromoacetateHCID 10796Cesium carbonateHCID 679582-Trifluoromethylphenol

생성물 1

HCID 11354946Ethyl 2-(2-(trifluoromethyl)phenoxy)acetate

시약·촉매·용매 3

HCID 962Water용매HCID 6342Acetonitrile용매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 2-trifluoromethylphenol (1.62 g) in anhydrous acetonitrile was treated with cesium carbonate (3.25 g) and ethyl bromoacetate (1.75 g) and the reaction mixture stirred at room temperature for 2 hours. The reaction mixture was diluted with water and ethyl acetate and the organic layer washed with water and dried with brine and over sodium sulfate. Evaporation of ethyl acetate gave the title compound as a colourless oil.

후처리

  1. washthe organic layer washed with water
  2. dry with materialdried with brine and over sodium sulfate
  3. customEvaporation of ethyl acetate

출처 및 근거

ORD 기록
ord-6d696bea668f4b758ccefed342a68beb
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091237B2

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