Ethyl bromoacetate → Ethyl 2-(2-(trifluoromethyl)phenoxy)acetate
반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9].C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]>C(#N)C.O.C(OCC)(=O)C>[CH2:23]([O:22][C:20](=[O:21])[CH2:19][O:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:10])([F:11])[F:1])[CH3:24]참가 물질
7
실험 절차
A mixture of 2-trifluoromethylphenol (1.62 g) in anhydrous acetonitrile was treated with cesium carbonate (3.25 g) and ethyl bromoacetate (1.75 g) and the reaction mixture stirred at room temperature for 2 hours. The reaction mixture was diluted with water and ethyl acetate and the organic layer washed with water and dried with brine and over sodium sulfate. Evaporation of ethyl acetate gave the title compound as a colourless oil.
후처리
- washthe organic layer washed with water
- dry with materialdried with brine and over sodium sulfate
- customEvaporation of ethyl acetate
출처 및 근거
- ORD 기록
- ord-6d696bea668f4b758ccefed342a68beb
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07091237B2
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