2-Chloroquinoline → Quinoline, 2-hydrazinyl-

HRID 962753

반응식

HRID 962753 반응식
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.O.[NH2:13][NH2:14]>C(O)C.O>[N:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH:10]=[CH:11][C:2]=1[NH:13][NH2:14]

참가 물질

5

반응물 2

HCID 119282-ChloroquinolineHCID 24654Hydrazine hydrate (1:1)

생성물 1

HCID 85111Quinoline, 2-hydrazinyl-

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a solution of 2-chloroquinoline (15 g) in ethanol (150 ml) was added hydrazine hydrate (40 ml) the resulting solution was heated at reflux for 6 hrs then diluted with water (400 ml) and extracted with diethyl ether (3×200 ml). The collected organic phase was washed with brine (300 ml), dried and concentrated under vacuum to afforg the title compound as a solid (13 g)

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 6 hrs
  3. extractionextracted with diethyl ether (3×200 ml)
  4. washThe collected organic phase was washed with brine (300 ml)
  5. customdried
  6. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-bf4824fec83f4f6487b276a291e8fc17
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05760059

연결된 노트

불러오는 중…