Acrylonitrile → 3-(3-Iodo-phenylamino)-propionitrile

HRID 963410

반응식

HRID 963410 반응식
[I:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[C:9](#[N:12])[CH:10]=[CH2:11]>C([O-])(=O)C.[Cu+2].C([O-])(=O)C>[I:1][C:2]1[CH:3]=[C:4]([NH:5][CH2:11][CH2:10][C:9]#[N:12])[CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 7855AcrylonitrileHCID 122713-Iodoaniline

생성물 1

HCID 190816343-(3-Iodo-phenylamino)-propionitrile수율 37%

시약·촉매·용매 1

HCID 8895Cupric acetate촉매

실험 절차

13at) 4.38 g of 3-iodoaniline, 1.06 g of acrylonitrile and 0.5 g of copper-(II)acetate are mixed and held at 70° for 5 hrs. The mixture is chromatographed on silica gel with ethyl acetate/cyclohexane 1:4 and yields 2.01 g of 3-(3-iodo-phenylamino)-propionitrile as a brown oil. Yield: 37%. Mass spectrum: peak inter alia at m/e : 272 (M+, 50%), 232 (100%); 105 (35%).

후처리

  1. customThe mixture is chromatographed on silica gel with ethyl acetate/cyclohexane 1:4

출처 및 근거

ORD 기록
ord-c87e1452187a472ab805a0aa8f596f49
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05763450

연결된 노트

불러오는 중…