Thionyl Chloride → 4-(tert-Butyl)-2-(chloromethyl)pyridine

HRID 963491노트

반응식

HRID 963491 반응식
[C:1]([C:5]1[CH:10]=[CH:9][N:8]=[C:7]([CH2:11]O)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].S(Cl)([Cl:15])=O>C(Cl)(Cl)Cl>[C:1]([C:5]1[CH:10]=[CH:9][N:8]=[C:7]([CH2:11][Cl:15])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 18799645(4-(tert-Butyl)pyridin-2-yl)methanol

생성물 1

HCID 190813024-(tert-Butyl)-2-(chloromethyl)pyridine

시약·촉매·용매 1

HCID 6212Chloroform용매2회

반응 조건

온도
50 °C

실험 절차

To a solution of 4-tert-butyl-2-hydroxymethylpyridine (0.36 g) in chloroform (10 ml) was added dropwise a solution of thionyl chloride (1 ml) in chloroform (5 ml) at room temperature and the mixture was stirred for 3 hours at ca. 50° C., After cooling to room temperature, the resultant mixture was concentrated in vacuo. The residue was taken up with chloroform and washed with saturated sodium carbonate aqueous solution, dried over magnesium sulfate, filtered and concentrated in vacuo to give 4-tert-butyl-2-chloromethylpyridine (0.37 g) as a brown oil.

후처리

  1. temperatureAfter cooling to room temperature
  2. concentrationthe resultant mixture was concentrated in vacuo
  3. washwashed with saturated sodium carbonate aqueous solution
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-2a8966bd26994a7598edcf4c7e6a2a0c
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05763437

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