Allyl bromide → 2-[4-Fluorophenyl]ethyl allyl ether

HRID 963573

반응식

HRID 963573 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][OH:10])=[CH:4][CH:3]=1.[H-].[Na+].[CH2:13](Br)[CH:14]=[CH2:15]>CN(C=O)C>[CH2:15]([O:10][CH2:9][CH2:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)[CH:14]=[CH2:13]

참가 물질

5

반응물 3

HCID 7841Allyl bromideHCID 24758Sodium hydrideHCID 820684-Fluorophenethyl Alcohol

생성물 1

HCID 190822842-[4-Fluorophenyl]ethyl allyl ether수율 97.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2-[4-Fluorophenyl]ethanol (7.0 g) was added slowly to a stirred suspension of sodium hydride (1.25 g, 60% as dispersion in oil prewashed with petroleum ether bp 60°-80°) in DMF (50 ml). The mixture was stirred for 30 min at room temperature. Allyl bromide (6.0 g) was then added slowly and the whole allowed to stir overnight. The reaction was partitioned between water and ether. The aqueous layer was further extracted with ether and the combined ethereal extracts were washed with water and dried (MgSO4). The ether was removed under reduced pressure to yield the crude subtitled compound as a colourless oil (8.7 g, 96%).

후처리

  1. stirringto stir overnight
  2. customThe reaction was partitioned between water and ether
  3. extractionThe aqueous layer was further extracted with ether
  4. washthe combined ethereal extracts were washed with water
  5. dry with materialdried (MgSO4)
  6. customThe ether was removed under reduced pressure

출처 및 근거

ORD 기록
ord-38ddd61b2c5c4824a08344edaecd409e
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05763465

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