Hydrochloric Acid → Dihydro-7-(2-mercaptoethyl)-1-pyrindine-6,6-bisphosphonic acid

HRID 963642노트

반응식

HRID 963642 반응식
C([S:4][CH2:5][CH2:6][C:7]1[C:8]([P:24]([O:29]CC)(=[O:28])[O:25]CC)([P:16]([O:21]CC)(=[O:20])[O:17]CC)[CH:9]=[C:10]2[C:15]=1[NH:14][CH2:13][CH:12]=[CH:11]2)(=O)C.Cl>>[SH:4][CH2:5][CH2:6][C:7]1[C:8]([P:24]([OH:29])(=[O:25])[OH:28])([P:16]([OH:21])(=[O:17])[OH:20])[CH:9]=[C:10]2[C:15]=1[NH:14][CH2:13][CH:12]=[CH:11]2

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 86752760Dihydro-7-(2-acetylthioethyl)-1-pyrindine-6,6-bisphosphonic acid, tetraethyl ester

생성물 1

HCID 86752761Dihydro-7-(2-mercaptoethyl)-1-pyrindine-6,6-bisphosphonic acid

실험 절차

Dihydro-7-(2-acetylthioethyl)-1-pyrindine-6,6-bisphosphonic acid, tetraethyl ester (4.0 mmol) is added to 6N HCl (35 ml) and heated at reflux under nitrogen for 18 hours. The reaction mixture is then cooled and concentrated under reduced pressure. The product is obtained by recrystallizing from water and isopropanol.

후처리

  1. temperatureheated
  2. temperatureat reflux under nitrogen for 18 hours
  3. temperatureThe reaction mixture is then cooled
  4. concentrationconcentrated under reduced pressure
  5. customThe product is obtained
  6. customby recrystallizing from water and isopropanol

출처 및 근거

ORD 기록
ord-1601c17761b34246994f7fce36b6dcf2
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05763611

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