Benzyl Bromide → 4-(Benzyloxy)-2-chloro-1-nitrobenzene

HRID 963651

반응식

HRID 963651 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[CH2:12](Br)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 102833-Chloro-4-nitrophenolHCID 11430Potassium Carbonate

생성물 1

HCID 8198614-(Benzyloxy)-2-chloro-1-nitrobenzene

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 3-chloro-4-nitrophenol (10 g, 0.058 mole), benzyl bromide (11.8 g, 0.069 mole), and potassium carbonate (16 g, 0.116 mole) in acetone is stirred, heated at reflux temperature for 17 hours, cooled and filtered. The filtrate is concentrated in vacuo to give a solid residue which is recrystallized from absolute ethanol to give the title compound, mp 82°-84.5° C., identified by elemental and NMR analyses.

후처리

  1. temperatureheated
  2. temperatureat reflux temperature for 17 hours
  3. temperaturecooled
  4. filtrationfiltered
  5. concentrationThe filtrate is concentrated in vacuo
  6. customto give a solid residue which
  7. customis recrystallized from absolute ethanol

출처 및 근거

ORD 기록
ord-78f9cef888a24e68a2a625d65ec2517c
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05763615

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