Hydrochloric Acid → H-(L)-Pal-NH2
반응식
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:10]([NH2:12])=[O:11])[CH2:3][C:4]1[CH:9]=[N:8][CH:7]=[CH:6][CH:5]=1.Cl>C(Cl)Cl.O1CCOCC1>[NH2:1][C@H:2]([C:10]([NH2:12])=[O:11])[CH2:3][C:4]1[CH:9]=[N:8][CH:7]=[CH:6][CH:5]=1참가 물질
5
실험 절차
Suspend Boc-(L)-Pal-NH2 (0.98 g) in methylene chloride (15 mL) with light heating and add a solution of hydrochloric acid (4M, 10 mL) in dioxane. After 30 minutes evaporate methylene chloride and dioxane. Dissolve the solid in methanol, precipitate by addition of ether and filtrate to give H-(L)-Pal-NH2. 2HCl (0.86 g, 98%).
후처리
- temperatureheating
- customAfter 30 minutes evaporate methylene chloride and dioxane
- dissolutionDissolve the solid in methanol
- additionprecipitate by addition of ether and filtrate
출처 및 근거
- ORD 기록
- ord-d6373623d39543ca934f731c9d5e46e1
- 출처 데이터셋
- uspto-grants-1998_06
- 특허 번호
- US05766932
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