Triphenylphosphine → ({3-(Methoxycarbonyl)-5-[4-(trifluoromethyl)phenyl]-2-furyl}methyl)(triphenyl)phosphonium bromide

HRID 9649

반응식

HRID 9649 반응식
[Br:1][CH2:2][C:3]1[O:4][C:5]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)=[CH:6][C:7]=1[C:8]([O:10][CH3:11])=[O:9].[C:22]1([P:28]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C1(C)C=CC=CC=1>[Br-:1].[CH3:11][O:10][C:8]([C:7]1[CH:6]=[C:5]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)[O:4][C:3]=1[CH2:2][P+:28]([C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)([C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)=[O:9]

참가 물질

4

반응물 2

HCID 11776TriphenylphosphineHCID 21986318Methyl 2-bromomethyl-5-[4-(trifluoromethyl)phenyl]-3-furoate2회

생성물 1

HCID 86593915({3-(Methoxycarbonyl)-5-[4-(trifluoromethyl)phenyl]-2-furyl}methyl)(triphenyl)phosphonium bromide

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Methyl 2-bromomethyl-5-[4-(trifluoromethyl)phenyl]-3-furoate (intermediate 44, 0.20 g) was dissolved in toluene (3 ml) treated with triphenylphosphine (0.159 g) and heated to reflux for 1 hour. The reaction was allowed to cool and the white precipitate was collected by filtration, washed with fresh toluene to give the title compound as a white powder.

후처리

  1. temperatureheated
  2. temperatureto reflux for 1 hour
  3. temperatureto cool
  4. filtrationthe white precipitate was collected by filtration
  5. washwashed with fresh toluene

출처 및 근거

ORD 기록
ord-f6ddaba673be4decb2b45330286d6069
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091237B2

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