(3,5-Di-tert-butylphenyl)methanol → 3,5-Bis(tert-butyl)benzaldehyde

HRID 964927노트

반응식

HRID 964927 반응식
[C:1]([C:5]1[CH:6]=[C:7]([CH:10]=[C:11]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH:12]=1)[CH2:8][OH:9])([CH3:4])([CH3:3])[CH3:2]>O=[Mn]=O.C(Cl)(Cl)Cl>[C:13]([C:11]1[CH:10]=[C:7]([CH:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH:12]=1)[CH:8]=[O:9])([CH3:16])([CH3:15])[CH3:14]

참가 물질

4

반응물 1

HCID 12660843(3,5-Di-tert-butylphenyl)methanol

생성물 1

HCID 12682533,5-Bis(tert-butyl)benzaldehyde

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 6212Chloroform용매

반응 조건

온도
25 °C

실험 절차

To the crude alcohol from above was added MnO2 and CHCl3 (20 mL). The mixture was stirred overnight at 25° C. and filtered, and the organic solvent was evaporated. The crude residue was purified by flash chromatography on silica gel eluting with 1:6 ethyl acetate-hexane to give 0.3 g of 3,5-di-t-butylbenzaldehyde as a white solid.

후처리

  1. filtrationfiltered
  2. customthe organic solvent was evaporated
  3. customThe crude residue was purified by flash chromatography on silica gel eluting with 1:6 ethyl acetate-hexane

출처 및 근거

ORD 기록
ord-18eedb25bce74f04b968f52632084159
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05773421

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