Hydrogen Bromide → HCID 135829331, 화합물

HRID 964995노트

반응식

HRID 964995 반응식
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([Cl:13])=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1.C(=O)(O)[O-].[Na+].[BrH:19]>>[Cl:13][C:7]1[C:6]2[C:11](=[CH:12][C:3]([OH:2])=[CH:4][CH:5]=2)[N:10]=[C:9]([Br:19])[CH:8]=1

참가 물질

4

반응물 3

HCID 260Hydrogen BromideHCID 516892Sodium BicarbonateHCID 106078294-Chloro-7-methoxyquinoline

생성물 1

HCID 135829331HCID 135829331, 화합물

실험 절차

7-Methoxy-4-chloroquinoline(13 g, 67 mmol) was refluxed for 24 hours with 47% hydrobromic acid (30 ml). After allowing to cool, aqueous solution of saturated sodium bicarbonate was added for neutralization and the resulting crystals were filtered. The obtained crystals were washed with water, sufficiently dried and recrystallized from ethanol to obtain 9 g of 4-chloro(bromo)-7-hydroxyquinoline [a mixture of 4-chloro-7-hydroxyquinoline and 4-bromo-7-hydroxy-quinoline (7 : 3)]. This mixture was used without further purification as the starting material in a next reaction.

후처리

  1. temperatureto cool
  2. filtrationthe resulting crystals were filtered
  3. washThe obtained crystals were washed with water
  4. customsufficiently dried
  5. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-d8bd8009cdbb41e0951675139e9f6e04
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05773449

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