Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium borohydride → (4-Chloroquinolin-7-yl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | Methyl 4-chloroquinoline-7-carboxylate | HCID 21708520 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (4-Chloroquinolin-7-yl)methanol | HCID 22054610 | 30.4% |
반응 단계
7-Methoxycarbonyl-4-chloroquinoline(3.75 g, 0.017 mol) was dissolved in methanol (200 ml), added under ice-cooling with sodium borohydride (12.9 g, 0.34 mol) and stirred for an hour. The reaction mixture was poured into ice water. The resulting precipitates were collected by filtration, dried over phosphorus pentoxide and recrystallized from chloroform (20 ml) to obtain 1.0 g (30%) of 7-hydroxymethyl-4-chloroquinoline.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05773449 |
| 출처 데이터셋 | uspto-grants-1998_06 |
| ORD ID | ord-46de3671617c45bd83848ffcb82be690 |
| 출처 메모 | uspto-grants-1998_06 |