Perchloric Acid → HCID 22116111, 화합물
반응식
[Cl:1][CH2:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=O)[C:5]1=[O:14].Cl(O)(=O)(=O)=O>C(O)(=O)C.[Pd]>[Cl:1][CH2:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:14]참가 물질
5
실험 절차
1-(2-Chloroethyl)-lH-indol-2,3-dione (5.24 g) [C.A. Reg no. 77218-99-6] was suspended in acetic acid (50 ml) and hydrogenated at 60 p.s.i., at room temperature, in the presence of 70% perchloric acid (0.2 ml) and 5% palladium on charcoal (1 g) for 24 hours. The clear solution was filtered and concentrated under reduced pressure. The residue was purified by chromatography on silica gel, eluent chloroform, to give 1-(2-chloroethyl)-1,3-dihydro-2H-indol-2-one as a white solid.
후처리
- filtrationThe clear solution was filtered
- concentrationconcentrated under reduced pressure
- customThe residue was purified by chromatography on silica gel, eluent chloroform
출처 및 근거
- ORD 기록
- ord-e50f9d551456438196f57063bd6952ee
- 출처 데이터셋
- uspto-grants-1998_06
- 특허 번호
- US05773448
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