Triphosgene → HCID 19076265, 화합물

HRID 965316노트

반응식

HRID 965316 반응식
[NH2:1][N:2]1[CH:10]=[C:8]([CH3:9])[C:6](=[O:7])[NH:5][C:3]1=[O:4].[Cl:11][C:12](Cl)([O:14]C(=O)OC(Cl)(Cl)Cl)Cl>O1CCCC1>[Cl:11][C:12]([NH:1][N:2]1[CH:10]=[C:8]([CH3:9])[C:6](=[O:7])[NH:5][C:3]1=[O:4])=[O:14]

참가 물질

4

반응물 2

HCID 94429TriphosgeneHCID 118191591-Amino thymine

생성물 1

HCID 19076265HCID 19076265, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
0 °C

실험 절차

1-Amino thymine (7, 12.5 g, 0.1 mol) is dissolved in tetrahydrofuran (500 mL) and the solution is cooled to 0° C. and a 2M solution of triphosgene in THF (150 mL) is added and the reaction is stirred for 4 hours. The solution is evaporated to a solid, which is used as is in the next reaction.

후처리

  1. customThe solution is evaporated to a solid, which
  2. customas is in the next reaction

출처 및 근거

ORD 기록
ord-990b2642976f435da185362129b2b005
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05773571

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