Triethylamine → N-(2-Amino-5,6,7,8-tetrahydroquinazoline-4-yl)-N-(cyclohexylmethyl)amine
반응식
Cl[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[N:5]=[C:4]([NH2:12])[N:3]=1.C(N(CC)CC)C.[CH:20]1([CH2:26][NH2:27])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>C(O)CCC>[NH2:12][C:4]1[N:3]=[C:2]([NH:27][CH2:26][CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[N:5]=1참가 물질
5
실험 절차
A mixture of 4-chloro-5,6,7,8-tetrahydroquinazoline-2-ylamine (107 mg, 0.58 mmol), triethylamine (221 mg, 2.18 mmol), cyclohexylmethylamine (132 mg, 1.17 mmol) and n-butanol (3 ml) was reacted for 4 hours at 80-90° C. According to the post-treatment of Example 1, the object compound was obtained (102 mg, 67.9%).
후처리
- customwas reacted for 4 hours at 80-90° C
- customthe object compound was obtained (102 mg, 67.9%)
출처 및 근거
- ORD 기록
- ord-817dbfaba3fe4baca71bc3806d40cb49
- 출처 데이터셋
- uspto-grants-2005_10
- 특허 번호
- US06951866B2
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