Lithium Hydroxide → 5-Amino-6-chloroimidazo[1,2-a]pyridine-8-carboxylic acid

HRID 965790노트

반응식

HRID 965790 반응식
[NH2:1][C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[C:5]([C:11]([O:13]CC)=[O:12])=[CH:4][C:3]=1[Cl:16].[OH-].[Li+]>CO>[NH2:1][C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[C:5]([C:11]([OH:13])=[O:12])=[CH:4][C:3]=1[Cl:16]

참가 물질

4

반응물 2

HCID 3939Lithium HydroxideHCID 12088090Ethyl 5-amino-6-chloroimidazo[1,2-a]pyridine-8-carboxylate

생성물 1

HCID 120880915-Amino-6-chloroimidazo[1,2-a]pyridine-8-carboxylic acid수율 86%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a stirred solution of ethyl 5-amino-6-chloroimidazo[1,2-a]pyridine-8-carboxylate (Example 1, METHOD A, Step 3, 217 mg, 0.91 mmol) in methanol (5 mL) was added 1N aqueous lithium hydroxide (500 μL) and the mixture was stirred overnight at room temperature. The solvent was removed in vacuo and acidified with 1N hydrochloric acid. The resultant precipitate was collected by filtration to give 165 mg (86%) of the title compound as a white solid.

후처리

  1. customThe solvent was removed in vacuo
  2. filtrationThe resultant precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-6f4e84dcb75f4f718cab610a33144212
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06951867B2

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