Oxalic Acid → 5-AMINO-6-CHLORO-2-ETHYL-N-{[1-(2-HYDROXYBUTYL)PIPERIDIN-4-YL]METHYL}IMIDAZO[1,2-a]PYRIDINE-8-CARBOXAMIDE OXALATE

HRID 965810노트

반응식

HRID 965810 반응식
[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([CH2:11][CH3:12])[N:10]=[C:6]2[C:5]([C:13]([NH:15][CH2:16][CH:17]2[CH2:22][CH2:21][N:20]([CH2:23][CH:24]([OH:27])[CH2:25][CH3:26])[CH2:19][CH2:18]2)=[O:14])=[CH:4][C:3]=1[Cl:28].[C:29]([OH:34])(=[O:33])[C:30]([OH:32])=[O:31]>CO>[C:29]([OH:34])(=[O:33])[C:30]([OH:32])=[O:31].[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([CH2:11][CH3:12])[N:10]=[C:6]2[C:5]([C:13]([NH:15][CH2:16][CH:17]2[CH2:18][CH2:19][N:20]([CH2:23][CH:24]([OH:27])[CH2:25][CH3:26])[CH2:21][CH2:22]2)=[O:14])=[CH:4][C:3]=1[Cl:28]

참가 물질

4

반응물 2

HCID 971Oxalic AcidHCID 103413815-amino-6-chloro-2-ethyl-N-{[1-(2-hydroxybutyl)piperidin-4-yl]methyl}-imidazo[1,2-a]pyridine-8-carboxamide

생성물 1

HCID 223132655-AMINO-6-CHLORO-2-ETHYL-N-{[1-(2-HYDROXYBUTYL)PIPERIDIN-4-YL]METHYL}IMIDAZO[1,2-a]PYRIDINE-8-CARBOXAMIDE OXALATE수율 142.1%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

5-amino-6-chloro-2-ethyl-N-{[1-(2-hydroxybutyl)piperidin-4-yl]methyl}-imidazo[1,2-a]pyridine-8-carboxamide (Example 13, Step 3, 79 mg, 0.19 mmol) was dissolved in methanol (3 mL) and acidified with oxalic acid (17.4 mg, 0.13 mmol) in methanol (2 mL). The mixture was then concentrated and a white precipitate was washed with ethyl acetate to afford (92 mg, 80%) of the title compound.

후처리

  1. concentrationThe mixture was then concentrated
  2. washa white precipitate was washed with ethyl acetate

출처 및 근거

ORD 기록
ord-51e857823e564950b4b992938bd17c0f
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06951867B2

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