4-Chloroaniline → N-(4-chlorophenyl)piperidin-4-amine

HRID 965893노트

반응식

HRID 965893 반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=O)(C)(C)C.[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=1.[Na]>ClCCl.C(O)(=O)C.FC(F)(F)C(O)=O>[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22][CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[CH:18][CH:17]=1

참가 물질

7

반응물 3

HCID 78124-ChloroanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 5360545Sodium

생성물 1

HCID 7183033N-(4-chlorophenyl)piperidin-4-amine

시약·촉매·용매 3

HCID 176Acetic Acid용매HCID 6344Dichloromethane용매2회HCID 6422Trifluoroacetic acid용매

실험 절차

Was synthesised in the same way as (A) from 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (3.59 g, 18.0 mmol), 4-chloro-phenylamine (1.15 g, 9.0 mmol) and sodium triacetoxyborhydride (5.34 g, 25.2 mmol) in dichloromethane (40 ml) and acetic acid (3.1 ml). The deprotection was run in dichloromethane (37 ml) and trifluoro acetic acid (18 ml). Yield 1.5 g, 79%.

출처 및 근거

ORD 기록
ord-aa69863d6b364afb9e8233d4be5564d3
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06951874B2

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