Bromine → 5-Bromo-3-methylthiophene-2-carbaldehyde

HRID 9659

반응식

HRID 9659 반응식
[CH3:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]=[O:8].[Br:9]Br>C(Cl)(Cl)Cl>[Br:9][C:5]1[S:4][C:3]([CH:7]=[O:8])=[C:2]([CH3:1])[CH:6]=1

참가 물질

4

반응물 2

HCID 24408BromineHCID 799113-Methyl-2-thiophenecarboxaldehyde

생성물 1

HCID 151154075-Bromo-3-methylthiophene-2-carbaldehyde

시약·촉매·용매 1

HCID 6212Chloroform용매3회

반응 조건

온도
100 °C

실험 절차

A solution of 3-methyl-thiophene-2-carboxaldehyde (12.0 g) in chloroform (50 ml) was added drop-wise to bromine (5.1 ml) in chloroform over 30 minutes and then heated to 100° C. for 140 minutes. The reaction mixture was diluted with chloroform and washed with 10% aqueous sodium thiosulfate solution, saturated aqueous bicarbonate solution and water. The organic solution was dried over magnesium sulfate and concentrated. The product isolated after evaporation of the solvent was further purified by vacuum distillation (122° C., 4 mbar) to give the title compound as a green oil.

후처리

  1. washwashed with 10% aqueous sodium thiosulfate solution, saturated aqueous bicarbonate solution and water
  2. dry with materialThe organic solution was dried over magnesium sulfate
  3. concentrationconcentrated
  4. customThe product isolated
  5. customafter evaporation of the solvent
  6. distillationwas further purified by vacuum distillation (122° C., 4 mbar)

출처 및 근거

ORD 기록
ord-68d53e10beee4f048db9f744e8204245
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091237B2

연결된 노트

불러오는 중…