Iodine → 2-(4-Bromo-2-chlorophenyl)-1,3-oxazole
반응식
[Br:1][C:2]1[CH:13]=[CH:12][C:5]([C:6]([NH:8][CH2:9][CH:10]=[O:11])=O)=[C:4]([Cl:14])[CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.II.C(N(CC)CC)C>C(Cl)Cl>[Br:1][C:2]1[CH:13]=[CH:12][C:5]([C:6]2[O:11][CH:10]=[CH:9][N:8]=2)=[C:4]([Cl:14])[CH:3]=1참가 물질
6
실험 절차
To a stirred solution of 4-bromo-2-chloro-N-(2-oxoethyl)benzamide (1.00 g, 3.617 mmol) in CH2Cl2 (30 mL) were added triphenylphosphine (1.90 g, 7.234 mmol), iodine (1.84 g, 7.234 mmol) and triethylamine (2.0 mL, 14.47 mmol) at room temperature. After 24 hour, the mixture was washed with water (20 mL), dried over MgSO4. Removal of the solvent, gave an oily recidue, which was purified by flash chromatography eluting with ethyl acetate/hexane (1/5) to give title compound (0.185 g, 20% yield).
후처리
- washthe mixture was washed with water (20 mL)
- dry with materialdried over MgSO4
- customRemoval of the solvent
- customgave an oily recidue, which
- customwas purified by flash chromatography
- washeluting with ethyl acetate/hexane (1/5)
출처 및 근거
- ORD 기록
- ord-ac43222cdd35487ebf128bdea4dbd085
- 출처 데이터셋
- uspto-grants-2005_10
- 특허 번호
- US06951876B2
반응 노트
불러오는 중…