HCID 69733344, 화합물 → HCID 10067963, 화합물

HRID 966104노트

반응식

HRID 966104 반응식
Cl.[OH:2][C:3]1[C:4]([O:27][CH3:28])=[C:5]([C:10](=[O:26])[CH2:11][NH:12][C:13]([CH3:25])([CH3:24])[CH2:14][C:15]2[C:20]([CH3:21])=[CH:19][C:18]([CH3:22])=[CH:17][C:16]=2[CH3:23])[CH:6]=[CH:7][C:8]=1[OH:9]>CO.[Pt](=O)=O>[CH3:25][C:13]([NH:12][CH2:11][CH:10]([C:5]1[C:4]([O:27][CH3:28])=[C:3]([OH:2])[C:8]([OH:9])=[CH:7][CH:6]=1)[OH:26])([CH3:24])[CH2:14][C:15]1[C:20]([CH3:21])=[CH:19][C:18]([CH3:22])=[CH:17][C:16]=1[CH3:23]

참가 물질

4

반응물 1

HCID 69733344HCID 69733344, 화합물

생성물 1

HCID 10067963HCID 10067963, 화합물

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 887Methanol용매

실험 절차

9 g of 1-(3,4-dihydroxy-2-methoxyphenyl)-2-[1,1-dimethyl-2-(2,4,6-trimethylphenyl)-ethylamino]ethanone hydrochloride is hydrogenated with 0.4 g of platinum(IV) oxide in 125 mL of methanol. The catalyst is filtered off and the solvent is distilled off under reduced pressure. The residue is dissolved in 50 mL of ethyl acetate and the precipitated crystals are suction filtered and washed with diethyl ether and ethyl acetate. Yield: 6 g (67%, hydrochloride); melting point: 98° C.-105° C.

후처리

  1. filtrationThe catalyst is filtered off
  2. distillationthe solvent is distilled off under reduced pressure
  3. dissolutionThe residue is dissolved in 50 mL of ethyl acetate
  4. filtrationfiltered
  5. washwashed with diethyl ether and ethyl acetate

출처 및 근거

ORD 기록
ord-74c2ff880a7240749afd9141298e556e
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06951888B2

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