HCID 22314541, 화합물 → HCID 69725567, 화합물

HRID 966105노트

반응식

HRID 966105 반응식
[CH3:1][C:2]([NH:11][CH2:12][C:13]([C:15]1[CH:35]=[CH:34][C:18]2[O:19]C(C3C=CC=CC=3)(C3C=CC=CC=3)[O:21][C:17]=2[C:16]=1[O:36][CH3:37])=[O:14])([CH3:10])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>Cl>[OH:21][C:17]1[C:16]([O:36][CH3:37])=[C:15]([C:13](=[O:14])[CH2:12][NH:11][C:2]([CH3:1])([CH3:10])[CH2:3][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH:35]=[CH:34][C:18]=1[OH:19]

참가 물질

3

반응물 1

HCID 22314541HCID 22314541, 화합물

생성물 1

HCID 69725567HCID 69725567, 화합물

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매2회

실험 절차

34 g of the HCl salt of 2-(1,1-dimethyl-2-phenylethylamino)-1-(4-methoxy-2,2-diphenylbenzo[1,3]dioxol-5-yl)ethanone is refluxed in 340 mL of 15% methanolic hydrochloric acid for 2 hours. Then the solvent is distilled off under reduced pressure and the residue is dissolved in ethyl acetate. The solid precipitated is suction filtered and washed with ethyl acetate and diethyl ether. Yield: 18 g (77%, hydrochloride); melting point: 192° C.-196° C.

후처리

  1. distillationThen the solvent is distilled off under reduced pressure
  2. dissolutionthe residue is dissolved in ethyl acetate
  3. customThe solid precipitated
  4. filtrationfiltered
  5. washwashed with ethyl acetate and diethyl ether

출처 및 근거

ORD 기록
ord-9e9be5236d7448fa8420eea1fceeea77
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06951888B2

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