Isobutyraldehyde → N-Isobutyl-N,O-dibenzylhydroxylamine

HRID 966437노트

반응식

HRID 966437 반응식
[CH2:1]([NH:8][O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:17][CH:18]([CH3:21])[CH:19]=O.CC1C=CC(S([O-])(=O)=O)=CC=1.C1C=C[NH+]=CC=1>C1COCC1.CO>[CH2:17]([N:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH:18]([CH3:21])[CH3:19]

참가 물질

5

반응물 3

HCID 6561IsobutyraldehydeHCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 11063773N,O-Dibenzylhydroxylamine

생성물 1

HCID 12045652N-Isobutyl-N,O-dibenzylhydroxylamine

시약·촉매·용매 1

HCID 21899815MeOH tetrahydrofuran용매

실험 절차

To a solution of II (1 eq.), 2-methylpropanal (1 eq.) and BH3(pyridine) (1 eq.) in THF:MeOH (1:3) was added PPTS (1 eq.). The reaction mixture was stirred at rt for 12 h and afforded, after aqueous workup and purification by column chromatography, III as a colorless oil.

후처리

  1. customafforded
  2. customafter aqueous workup and purification by column chromatography, III as a colorless oil

출처 및 근거

ORD 기록
ord-0f37980ba90743f494180b45d7b29105
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06951958B1

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