반응식
[CH:1]([Si:4]([CH:16]([CH3:18])[CH3:17])([CH:13]([CH3:15])[CH3:14])[O:5][CH2:6][C:7]1[S:8][CH:9]=[CH:10][C:11]=1[CH3:12])([CH3:3])[CH3:2].C([Li])CCC.C(O[B:28]1[O:32][C:31]([CH3:34])([CH3:33])[C:30]([CH3:36])([CH3:35])[O:29]1)(C)C.[Cl-].[NH4+]>O1CCCC1>[CH:16]([Si:4]([CH:1]([CH3:3])[CH3:2])([CH:13]([CH3:15])[CH3:14])[O:5][CH2:6][C:7]1[S:8][C:9]([B:28]2[O:32][C:31]([CH3:34])([CH3:33])[C:30]([CH3:36])([CH3:35])[O:29]2)=[CH:10][C:11]=1[CH3:12])([CH3:18])[CH3:17]참가 물질
6
반응물 4
생성물 1
시약·촉매·용매 1
반응 조건
- 온도
- -78 °C
실험 절차
A mixture of triisopropyl[(3-methylthien-2-yl)methoxy]silane (intermediate 115, 1.42 g) in tetrahydrofuran (20 ml), stirred at −78° C. under nitrogen, was treated with 1.6M butyllithium in hexanes (3.9 ml). The reaction temperature was slowly allowed to rise to 0° C. over 2 hours and then re-cooled to −78° C. 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.28 ml) was added and the reaction stirred at this temperature for 4 hours and then warmed to 0° C. The reaction was added to a mixture of saturated ammonium chloride and ice. The aqueous mixture was extracted with diethyl ether and the organic solution dried with brine and over sodium sulfate. Evaporation of the solvent afforded the title compound as a white solid
후처리
- temperaturere-cooled to −78° C
- stirringthe reaction stirred at this temperature for 4 hours
- temperaturewarmed to 0° C
- extractionThe aqueous mixture was extracted with diethyl ether
- dry with materialthe organic solution dried with brine and over sodium sulfate
- customEvaporation of the solvent
출처 및 근거
- ORD 기록
- ord-cc8ff98036344a30b32617317c2cefd3
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07091237B2
연결된 노트
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