Dimethyl Carbonate → 5-Butyloxazolidine-2,4-dione

HRID 967350

반응식

HRID 967350 반응식
C(=O)(OC)OC.C[O-].[Na+].OC(CCCC)C(N)=O.[Na].[CH2:20]([CH:24]1[O:28][C:27](=[O:29])[NH:26][C:25]1=[O:30])[CH2:21][CH2:22][CH3:23]>>[CH2:20]([CH:24]1[O:28][C:27](=[O:29])[NH:26][C:25]1=[O:30])[CH2:21][CH2:22][CH3:23]

참가 물질

5

반응물 4

HCID 12021Dimethyl CarbonateHCID 9833961Hexanamide, 2-hydroxy-2회HCID 10942334Sodium MethoxideHCID 697451525-Butyl-oxazolidin-2,4-dione sodium salt

생성물 1

HCID 99422045-Butyloxazolidine-2,4-dione

실험 절차

To this solution, dimethyl carbonate (74 g, 0.82 mol) and 30% sodium methylate (147 g, 0.82 mol) were again added and reacted at from 60 to 70° C. for 2 hours. Thereafter, a part of the reaction solution was sampled and the components of the reaction solution were analyzed by HPLC, as a result, the concentration of 2 -hydroxyhexanoic acid amide was 0 mass % in the solution and the concentration of 5-butyl-oxazolidin-2,4-dione sodium salt as the objective product was 27.5% in the solution. From these analysis values, the conversion of 2-hydroxyhexanoic acid amide was 100% and the yield in terms of 5-butyl-oxazolidin-2,4-dione was 94.1%.

후처리

  1. customreacted at from 60 to 70° C. for 2 hours
  2. aliquotThereafter, a part of the reaction solution was sampled

출처 및 근거

ORD 기록
ord-6ed295e945f54a10bc8d1d05858e51f3
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06953859B2

연결된 노트

불러오는 중…